For other uses, see. Sildenafil, sold as the brand name. Viagra among others, is a what is viagra used for medication used to treat erectile dysfunction and pulmonary arterial hypertension. 3, its effectiveness for treating sexual dysfunction in women has not been demonstrated. 3, common side effects include headaches and heartburn, as well as flushed skin. Caution is advised in those who have cardiovascular disease. Rare but serious side effects include prolonged erections, which can lead how effective is viagra to damage to the penis, what is viagra used for and sudden-onset hearing loss. Sildenafil should not be taken by people who take nitrates such as nitroglycerin (glycerin trinitrate as this may result in a severe and potentially fatal drop can you take 2 viagra pills at once in blood pressure. 3, sildenafil acts by inhibiting cGMP-specific phosphodiesterase type 5 (phosphodiesterase 5, PDE5 an enzyme that promotes degradation of cGMP, which regulates blood flow in the penis. Pfizer scientists, andrew Bell, David Brown, and Nicholas Terrett originally discovered sildenafil as a treatment for various cardiovascular disorders. 4 5, since becoming available in 1998, sildenafil has been a common treatment for erectile dysfunction; its primary competitors are tadalafil (trade name Cialis) and vardenafil (Levitra). Contents fucking on viagra Medical uses 50mg tablets of sildenafil Sexual dysfunction The primary indication of sildenafil is treatment of erectile dysfunction (inability to sustain a satisfactory erection to complete intercourse). Its use is now one of the standard treatments for erectile dysfunction, including for men with diabetes mellitus. 6 Antidepressant-associated sexual dysfunction Tentative evidence suggests that sildenafil may help men who experience antidepressant -induced erectile dysfunction. 7 Pulmonary hypertension While sildenafil improves some markers of disease in people with pulmonary arterial hypertension, it does not appear to affect the risk of death or serious side effects as of 2014. 8 Raynaud's phenomenon Sildenafil and other PDE5 inhibitors are used off-label to alleviate vasospasm and treat severe ischemia and ulcers in fingers and toes for people with secondary what is viagra used for Raynaud's phenomenon ; 9 10 these drugs have moderate efficacy for reducing the frequency and duration. 9 As of 2016, their role more generally in Raynaud's was not clear. 10 Adverse effects In clinical trials, the most common adverse effects of sildenafil use included headache, flushing, indigestion, nasal congestion, and impaired vision, including photophobia and blurred vision. 2 Some sildenafil users have complained of seeing everything tinted blue ( cyanopsia ). 11 Some complained of blurriness and loss of peripheral vision. In July 2005, the FDA found that sildenafil could lead to vision impairment viagra commercial in rare cases 12 and a number of studies have linked sildenafil use with non-arteritic anterior ischemic optic neuropathy. 13 Rare but serious adverse effects found through postmarketing surveillance include prolonged erections, severe low blood pressure, myocardial infarction (heart attack ventricular arrhythmias, stroke, increased intraocular pressure, and sudden hearing loss. 2 In October 2007, the FDA announced that the labeling for all PDE5 inhibitors, including sildenafil, required a more prominent warning of the potential risk of sudden hearing loss. 14 Interactions Care should be exercised by people who are also taking protease what is viagra used for inhibitors for the treatment of HIV infection. Protease inhibitors inhibit the metabolism of sildenafil, effectively multiplying the plasma levels of sildenafil, increasing the incidence and severity of side effects. Those using protease inhibitors are recommended to limit their use of sildenafil to no more than one 25 mg dose every 48 hours. 2 Other drugs that interfere with the metabolism of sildenafil include erythromycin and cimetidine, both generic viagra pictures of which can also lead to prolonged plasma half-life levels.

How was viagra discovered

By, mary Bellis, updated October 29, 2017, according to the how was viagra discovered British Press, Peter Dunn and Albert Wood are named as the inventors of the process by which Viagra was created. Their names appeared on an application by Pfizer to patent (wowo9849166A1) the manufacturing process of Sildenafil Citrate, better known. Peter Dunn and Albert Wood are both employees how was viagra discovered of Pfizer Pharmaceuticals at the Pfizer run research laboratories in Kent and thus are not allowed to discuss their status or non-status as inventors. In a statement Albert Wood said: "I can't say anything, you'll have to talk to the press office.". On the invention of Viagra, a Pfizer Pharmaceuticals spokesperson said: "Life might seem cruel, but they are paid to work for the company and the company owns their inventions. Literally hundreds of people at Pfizer have been involved in developing the drug. You can't really point to two individuals and say they spawned Viagra.". More of a Team Effort, anyhow, to the best of our knowledge, this is how the story goes. In 1991, inventors Andrew Bell,. David Brown and. Nicholas Terrett discovered that chemical compounds belonging to the pyrazolopyrimidinone class were useful in treating heart problems such as angina. Some experts consider Terrett as the father of Viagra as he how was viagra discovered was named in the 1991 British patent for Sildenafil (tradenamed Viagra) as a possible heart medicine. It was in I994, though, that Terrett and his colleague Peter Ellis discovered during the trial studies of Sildenafil as a potential heart medication that it also increased blood flow to the penis, allowing men to reverse erectile dysfunctions. The drug acts by enhancing the smooth muscle relaxant effects of nitric oxide, a chemical that is normally released in response to sexual stimulation. The smooth muscle relaxation allows increased blood flow into the penis, leading to an erection when combined with something arousing. While Terrett is not allowed to discuss whether he considers himself the real inventor of Viagra as he is still a Pfizer employee, he did once state: "There were three how was viagra discovered patents put forward for Viagra. Basically me and my team discovered how useful the drug might. They (Wood and Dunn) created a way of mass producing it only.". Pfizer claims that hundreds of inventors were involved with the creation of Viagra and that there was not enough room on the patent application to name them all. Thus, only the department heads were listed. Simon Campbell, who until recently was the Senior Vice President Of Medicinal Discovery at Pfizer and oversaw Viagra's development, is considered by the American press to be the inventor of Viagra. However, Campbell would rather be remembered as the father of Amlodipine, a cardiovascular drug. Steps In Making Viagra, dunn and Wood worked on the crucial nine-step process to synthesize a Sildenafil (Viagra) compound into a pill. It was approved by the FDA on March 27, 1998 as the first pill to treat impotence. Here is a quick summary of the steps: Methylation of 3-propylpyrazole-5-carboxylic acid ethyl ester with hot dimethyl sulfate. Hydrolysis with aqueous NaOH to free acid. Nitration with oleum/fuming nitric acid, carboxamide formation with refluxing thionyl chloride/NH4OH. Reduction of nitro group to amino. Acylation with 2-ethoxybenzoyl chloride, cyclization, sulfonation to the chlorosulfonyl derivative, condensation with 1-methylpiperazine. Empirical formula C22H30N6O4S molecular weight 474.5 solubility.5 mg/mL how was viagra discovered in water, viagra and Lawsuits, one billion dollars in sales were made in Viagra's first year of production. But soon many lawsuits against how was viagra discovered Viagra and Pfizer were filed. This included a suit filed for 110 million dollars on behalf of Joseph Moran, a car dealer from New Jersey. He claimed that he crashed his car into two parked cars after Viagra caused him to see blue lightning coming from his fingertips, at which point he blacked out. Joseph Moran was driving his Ford thunderbird home after a date at the time. There are many facts in history of medicine when appearance of surprising discoveries was result of random observations or findings.

Is viagra bad for you

Generic Name: Sildenafil, tablets erectile Dysfunction ) (sil DEN a fil brand Name: Viagra. Medically reviewed on May 2, 2018, uses of, viagra : It is used to treat erectile dysfunction (ED). It may be given to you for other reasons. Talk with the doctor. What do I need to tell my doctor before I take. If you have an allergy to sildenafil or any other part. Viagra (sildenafil tablets (erectile dysfunction). If you are allergic to any drugs like this one, any other drugs, foods, is viagra bad for you or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives ; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs. If you have a health problem called pulmonary veno-occlusive disease (pvod). If you use drugs called "poppers" like amyl nitrite and butyl nitrite. If you are taking any of these drugs: Isosorbide dinitrate, isosorbide mononitrate, nitroglycerin, riociguat, or ritonavir. If you are taking another drug that has the same drug. If you are taking another drug like this one that is used to treat erectile dysfunction (ED) or high pressure in the lungs. If you have been told that you are not healthy enough to have sex. If you are a woman. This is viagra bad for you medicine is not approved for use in women. If the patient is a child. This medicine is not approved for use in children. This is not a list of all drugs or health problems that interact with Viagra (sildenafil tablets (erectile dysfunction). Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins ) and health problems. You must check to make sure that it is safe for you to take Viagra (sildenafil tablets (erectile dysfunction) with all of your drugs and health problems. Do not start, stop, or change is viagra bad for you the dose of any drug without checking with your doctor. What are some things I need to know or do while I take Viagra? Tell all of your health care providers that you take Viagra (sildenafil tablets (erectile dysfunction). This includes your doctors, nurses, pharmacists, and dentists. Avoid driving and doing other tasks or actions that call for you to be alert until you see how Viagra (sildenafil tablets (erectile dysfunction) affects you. To lower the chance of feeling dizzy or passing out, rise slowly if is viagra bad for you you have been sitting or lying down. Be careful going up and down stairs. Talk with your doctor before you drink alcohol. Rarely, certain side effects like abnormal heartbeat, heart attack, stroke, bleeding in the lungs, and very bad high blood pressure have happened with Viagra (sildenafil tablets (erectile dysfunction). Sometimes, this has been deadly. Most of the time, these problems happened in people who had heart problems before taking Viagra (sildenafil tablets (erectile dysfunction). It is not known if Viagra (sildenafil tablets (erectile dysfunction) caused these problems. If you have questions, talk with the doctor. A very bad eye problem has rarely happened with Viagra (sildenafil tablets (erectile dysfunction). This may lead to a change in eyesight and sometimes loss of eyesight, which may not come back. If you are 65 or older, use Viagra (sildenafil tablets (erectile dysfunction) with care. You could have more side effects.

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